RPBC - Region-Preserving Batch Correction for Paired Region-Resolved Single-Cell Data

Implements Region-Preserving Batch Correction (RPBC), an empirical-Bayes location-scale framework for paired region-resolved single-cell and spatial-omics data. RPBC preserves a patient-balanced population-average regional contrast while harmonizing patient-wide location shifts, patient-specific regional deviations, and patient-region scale heterogeneity. The package also provides Adaptive RPBC for group-size-dependent stabilization of patient-region scale variation and covariate-adjusted RPBC for preserving prespecified patient-level covariate-associated variation during harmonization. RPBC is designed to interoperate with Bioconductor data structures for single-cell and spatial experiments.